Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

多维格局的求是精神——评王辉斌教授《李白求是录》     

张春义  王莉娟 《贵阳金筑大学学报》2001,(4)

王辉斌教授李白研究力著《李白求是录》出版了,这是近年来李白研究的最新成果。作者从动态型式的整体观照、多元视角的系统思维、宏微互渗的立体态势等多维格局去研究李白,使人窥视到李白学术研究纵深处的许多壶奥,因而此书在还原历史真相的同时又具有方法论的深远意义。  相似文献   

改良小梁切除与传统小梁切除的疗效观察研究     

陈世会  黄胜 《铜仁职业技术学院学报》2006,(4)

目的:评价小梁切除术中改良巩膜瓣、睫状突定量小梁切除、不同缝合方式在术中术后的优缺点及远期疗效。方法120例(156眼)原发性青光眼随机分为4组:A组(传统术式组)30例(42眼);B组(可拆褥式缝线组)30例(40眼);C组(L形巩膜瓣小梁切除组)30例(34眼);D组(小切口睫状突定量小梁切除术组)3 0例(40眼),B.C.D组为改良术式组。比较4组术后浅前房、眼压和滤过泡情况。结果:浅前房发生率:A组26.119%(11/42),B组7.50%(3/40),C组2.94%(1/34),D组2.50%(1/40),改良术式组与传统术式组比较差异有板有统计学意义(P<0.01);随诊眼压:A组(14.65±4.30)mmHg,B组(1 3.87±3.60)m mHg,C组(15.58±3.20)mmHg,D组(14.50±3.15)mmHg,4组间差异无统计学意义(P>0.05);随诊功能性滤过泡A组76.19%(32/42),B组92.50%(37/40),C组97.05%(33/34),D组95.00%(38/40),传统小梁切除组与改良小梁切除组比较差异有统计学意义(P<0.05)。结论采用巩膜瓣可拆褥式缝合、L形巩膜瓣小梁切除、小切口睫状突定量小梁切除可大大降低术后浅前房的发生率,并能理想地控制眼压,提高术后视功能。  相似文献   

"优秀生心理综合症"及运动处方   总被引：1，自引：1，他引：0  

何新宏  安平 《体育成人教育学刊》2004,20(4):87-88

成绩优秀的学生往往存在一些特殊的心理问题，预防和消除优秀生的心理问题具有十分重要的意义。在进行体育教学和身体锻炼的同时，适当地运用运动处方，可以治疗优秀学生的心理疾病和消除心理障碍，促进优秀学生健康成长。  相似文献   

论英译汉中的常见错误与对策     

陈冬秀 《柳州师专学报》2004,19(4):51-55

分析了英译汉过程中的常见错误或问题(翻译综合症)，同时指出产生这些错误的原因，并在此基础上提出了解决问题的对策。  相似文献   

Effects of interval aerobic training combined with strength exercise on body composition,glycaemic and lipid profile and aerobic capacity of obese rats     

Irene Coll-Risco  Virginia A. Aparicio  Elena Nebot  Daniel Camiletti-Moirón  Rosario Martínez  Garyfallia Kapravelou 《Journal of sports sciences》2016,34(15):1452-1460

The purpose of this study was to investigate the effects of interval aerobic training combined with strength exercise in the same training session on body composition, and glycaemic and lipid profile in obese rats. Sixteen lean Zucker rats and sixteen obese Zucker rats were randomly divided into exercise and sedentary subgroups (4 groups, n = 8). Exercise consisted of interval aerobic training combined with strength exercise in the same training session. The animals trained 60 min/day, 5 days/week for 8 weeks. Body composition, lipid and glycaemic profiles and inflammatory markers were assessed.

Results showed that fat mass was reduced in both lean and obese rats following the exercise training (effect size (95% confidence interval (CI)) = 1.8 (0.5–3.0)). Plasma low-density lipoprotein–cholesterol and fasting glucose were lower in the exercise compared to the sedentary groups (d = 2.0 (0.7–3.2) and 1.8 (0.5–3.0), respectively). Plasma insulin was reduced in exercise compared to sedentary groups (d = 2.1 (0.8–3.4)). Some exercise × phenotype interactions showed that the highest decreases in insulin, homeostatic model assessment-insulin resistance, fasting and postprandial glucose were observed in the obese + exercise group (all, P < 0.01). The findings of this study suggest that interval aerobic training combined with strength exercise would improve body composition, and lipid and glycaemic profiles, especially in obese rats.  相似文献   

对虾白斑综合症病毒囊膜蛋白Vp28基因的克隆、表达及蛋白纯化     

吴小婷  陈曦  陈宇  刘斌  吴文林 《泉州师范学院学报》2011,29(4):41-44

以对虾白斑病毒DNA为模板扩增出Vp28基因,经限制性内切酶（SmaI,Not I）酶切后按正确的读码框顺序插入到pGEX-4T-2表达载体上,重组质粒转化大肠杆菌,经菌落PCR和质粒双酶切鉴定、序列测定确认,证实成功地构建了Vp28基因原核表达载体．转化菌经IPTG诱导表达,SDS-PAGE显示有与预期大小约52kD相吻合的融合蛋白带,18℃诱导24h后获得了可溶性表达的目的蛋白,采用Glutathione Sepharose 4B亲和层析对重组蛋白进行纯化,获得了纯度很高的目的蛋白．  相似文献   

脆性X染色体综合征的临床检测方法研究     

魏婷婷  周东蕊  张红琳  付文忠  张仁敏  杜彩贺  胡芳 《南京晓庄学院学报》2011,27(3):63-66

目的是建立一种简便、快捷的脆性X染色体综合征的临床检测方法.在常规PCR的基础上,采用热启动法,同时加入PCR增强剂Btaine、DMSO,对20例表型正常人群外周血样本进行FMR1基因（CGG）n重复序列检测.结果表明,改良后的FMR1基因PCR扩增技术能够高效扩增CG富集区,采用该方法我们检测了20例外周血样本均获得目标片段,PCR扩增产物片段长度400～500bp（相当于n=20～53）.因此,该方法简便、快速、经济而且重复性好,可用于群体普查和门诊快速筛查脆性X染色体综合征.  相似文献   

Discriminating Quantity: New Points for Teaching Children with Down Syndrome About Number?     

Jill Porter 《International Journal of Disability, Development & Education》2019,66(2):133-150

ABSTRACT

The focus of much mathematics teaching has been on the acquisition of counting, an area where children with Down syndrome can experience particular difficulties. Research with typically developing children has highlighted how early awareness of quantity provides a strong platform for the acquisition of later mathematical skills and programmes of early intervention have been introduced. Many of these studies are embedded in the work and traditions of developmental and cognitive psychology and can be difficult to access. Consequently, this is an area that has been largely ignored in the curricula of children with Down syndrome. This paper seeks to make this literature more available. It systematically reviews previous research with children with Down Syndrome on these early foundations. It considers seemingly contradictory findings in the light of differences in tasks, their presentation and instructions, and the responses required, in order to draw conclusions and reflect on the implications for teaching and learning. Some of these propositions are in contrast to existing practices and call for further research to test their effectiveness.  相似文献   

Unexpected changes of itinerary – adaptive functioning difficulties in daily transitions for adults with autism spectrum disorder     

Ewelina Rydzewska 《欧洲特需教育杂志》2016,31(3):330-343

Adaptive functioning skills, also known as adaptive behaviours, refer to a multifaceted concept defined as behaviours necessary for age-appropriate, independent functioning in social, communication, daily living or motor areas. In light of the growing population of children with ASD who will eventually become adults, increased understanding of adaptive functioning during the transition to adulthood is of importance, but current research in this area lacks first-hand evidence presenting adaptive skills difficulties among older adolescents and adults with ASD. This article focuses on adaptive functioning skills in daily transitions for adults with Asperger’s syndrome (AS) or high-functioning autism (HFA). It draws on evidence from 12 interviews with individuals on the autism spectrum age 16–43, and 2 focus groups with 8 family members of people affected by ASD. Particular emphasis is placed on impact of adaptive functioning difficulties on well-being and quality of life for adults with ASD. Grounded theory approach has been used to analyse the gathered data. Interviewees reflected on daily challenges associated with unexpected changes in routine, sensory difficulties and social interactions. These in turn had an impact on their adaptive functioning skills by introducing complications in the process of making transitions between different contexts and decreasing interviewees’ ability to tackle challenges of daily life. Importance placed on societal expectations towards meeting bespoken standards and conforming to norms ruling the structure and interactions of daily life were also widely discussed. Frequently such expectations did not allow for factoring in the developmental nature of ASD and related difficulties, which as a result triggered additional complexity in managing daily transitions for adults on the spectrum. Further research addressing adaptive functioning skills in daily transitions for adults with ASD is needed.  相似文献